Getting rejection errors when using Mailgun for email delivery

I’m having trouble with some emails getting bounced back when using Mailgun as my email service provider. I keep running into two main error types that are really frustrating me.

The first error says something like “550 Requested action not taken: mailbox unavailable invalid DNS MX or A/AAAA resource record” and the second one mentions “From: Domain is invalid. Please provide a valid From: IB506”.

I’m not sure if these problems are caused by something wrong with my setup or if it’s an issue on the recipient’s side. What steps should I take to troubleshoot and resolve these email delivery failures? Any help would be appreciated since this is affecting my ability to send important messages to users.

I’ve dealt with these Mailgun errors before - they’re usually DNS configuration problems that people miss during setup. The 550 error happens when your DNS records don’t match what Mailgun expects, and IB506 means Mailgun doesn’t recognize your domain as legitimate. Don’t assume everything’s set up right - check each piece systematically. First, make sure your domain shows “Active” in the Mailgun dashboard, not “Unverified” or “Pending”. Then use MXToolbox or similar tools to verify your DNS records propagated globally. Here’s what tripped me up: DNS changes can take way longer than you’d expect to fully propagate, so you might see random delivery failures even when you think everything’s working.

check ur api endpoint - sandbox domains dont work for production sends. also, make sure ur from address matches exactly what u verified in mailgun, including subdomains. i had the same issue, just a typo in my from field.

These delivery issues scream incomplete domain setup. I’ve hit this exact problem tons of times.

That 550 error? Recipient servers can’t validate your sending domain. The IB506 confirms your domain isn’t authenticated in Mailgun.

Usual fixes:

  • Make sure your sending domain is fully set up in Mailgun (not just added)
  • Check your SPF record includes Mailgun’s servers
  • Verify DKIM records are configured right
  • Your From address needs to match your verified domain exactly

Honestly though, manual email delivery is a nightmare. I automated my entire email workflow - error handling, retry logic, everything. When delivery fails, the system logs it, categorizes the error, and handles the response automatically.

Cut out 90% of my email problems. The automation checks domain verification, formats emails properly, and manages bounces without me touching anything.

You can build this automated email workflow at https://latenode.com

DNS MX errors typically indicate that the recipient’s email server may be misconfigured, so it’s essential to verify your domain authentication first. Ensure your domain is verified in Mailgun and that you’re sending from an authorized domain. IB506 errors occur when you’re using a domain that hasn’t been registered with your Mailgun account or when your From header doesn’t correspond to your verified domains. I’ve encountered similar issues while setting up Mailgun; adding my sending domain through their control panel and allowing for full propagation resolved most delivery problems. Additionally, examine your Mailgun logs for more detailed error information.

Both errors suggest issues with your DNS and domain configuration that need addressing. The first error, 550, typically indicates that Mailgun can’t locate the recipient’s mail server, often due to missing SPF and DKIM records for your domain. The second error, IB506, suggests that the From domain you’re using isn’t verified with Mailgun or is set up incorrectly in your account. I recommend checking your DNS settings using Mailgun’s domain verification tool to ensure all necessary TXT records are present. I faced a similar issue before; adjusting my SPF record to include Mailgun’s servers greatly improved my email delivery success.